Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum |
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| Authors: | Ran Zhang Zhihui Zhao Yaofeng Zhao Imre Kacskovics Marjolein van der Eijk Nanda de Groot |
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| Institution: | 1. State Key Laboratory of Agrobiotechnology, China Agricultural University , Beijing, People's Republic of China;2. Division of Clinical Immunology, Department of Laboratory Medicine , Karolinska Institute at Karolinska University Hospital Huddinge , Stockholm, Sweden;3. Division of Clinical Immunology, Department of Laboratory Medicine , Karolinska Institute at Karolinska University Hospital Huddinge , Stockholm, Sweden;4. Department of Animal Science , Agricultural Division, Jilin University , Changchun, Jilin, P. R. China;5. State Key Laboratory of Agrobiotechnology, China Agricultural University , Beijing, People's Republic of China;6. Department of Immunology , Institute of Biology, Faculty of Science, E?tv?s Loránd University , Budapest, Hungary;7. MucoVax Bv, Niels Bohrweg , Leiden, The Netherlands |
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| Abstract: | In this study, we evaluated haplotypes of the bovine FCGRT (encoding the FcRn heavy chain) and their relationship to the IgG concentration in bovine colostrum. Four single nucleotide polymorphism (SNP), classified into five haplotypes, were identified in a total of 49 Holstein-Frisians cows. Haplotype 5 was found to be significantly associated with a high IgG level (OR] = 9.90, 95%CI = 1.11–88.34, p = 0.016) and haplotype 2 exhibited a similar trend (OR] = 2.89, 95%CI = 1.17–7.11, p = 0.019). |
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| Keywords: | Bovine colostrum FCGRT IgG concentration Single nucleotide polymorphism |
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