Evaluation of the CTSL2 Gene as a Candidate Gene For Alopecia X in Pomeranians and Keeshonden |
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| Authors: | E-M Mausberg C Drögemüller G Dolf S Rüfenacht M Welle |
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| Institution: | 1. Institute of Genetics, DermFocus, Vetsuisse Faculty of the University of Berne , Berne, Switzerland;2. Institute of Genetics, Vetsuisse Faculty of the University of Berne , Berne, Switzerland;3. Dermatology Unit, Department of Clinical Veterinary Medicine , DermFocus, Vetsuisse Faculty, University of Berne , Berne, Switzerland;4. Institute of Animal Pathology, DermFocus, Vetsuisse Faculty of the University of Berne , Berne, Switzerland |
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| Abstract: | Alopecia X is a noninflammatory, progressive, bilateral symmetric alopecia in dogs. The disease is mainly found in Nordic breeds. The breed predisposition and a strong familial accumulation suggest a hereditary background. We analyzed the cathepsin L2 gene (CTSL2) as a candidate for alopecia X. The comparative sequencing of 14 affected and 18 control animals revealed ten polymorphisms; however, none of these polymorphisms affected the coding sequence. Haplotype analysis did not reveal an association of one particular CTSL2 haplotype with the disease phenotype; therefore, we conclude that the CTSL2 gene is probably not the causative gene for alopecia X. |
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| Keywords: | Alopecia X Black skin disease BSD Cathepsin L CTSL CTSL2 Dog |
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