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Gynaecological cancers and their cell lines |
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| Authors: | Kristijan Skok Lidija Gradišnik Uroš Maver Nejc Kozar Monika Sobočan Iztok Takač Darja Arko Rajko Kavalar |
| Institution: | 1. Department of pathology, General Hospital Graz II, Graz, Austria;2. Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Maribor, Slovenia;3. Division of Gynecology and Perinatology, University Medical Center Maribor, Maribor, Slovenia;4. Division of Gynecology and Perinatology, University Medical Center Maribor, Maribor, Slovenia
Faculty of Medicine, University of Maribor, Maribor, Slovenia Contribution: Formal analysis (equal), Investigation (equal), Writing - review & editing (equal);5. Faculty of Medicine, University of Maribor, Maribor, Slovenia |
| Abstract: | Cell lines are widely used for various research purposes including cancer and drug research. Recently, there have been studies that pointed to discrepancies in the literature and usage of cell lines. That is why we have prepared a comprehensive overview of the most common gynaecological cancer cell lines, their literature, a list of currently available cell lines, and new findings compared with the original studies. A literature review was conducted via MEDLINE, PubMed and ScienceDirect for reviews in the last 5 years to identify research and other studies related to gynaecological cancer cell lines. We present an overview of the current literature with reference to the original studies and pointed to certain inconsistencies in the literature. The adherence to culturing rulesets and the international guidelines helps in minimizing replication failure between institutions. Evidence from the latest research suggests that despite certain drawbacks, variations of cancer cell lines can also be useful in regard to a more diverse genomic landscape. |
| Keywords: | breast neoplasm cell line cervix cancer endometrial neoplasms gynaecology in vitro techniques pathology tumour cell line |