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Role of melatonin in the dynamics of acute spinal cord injury in rats |
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| Authors: | Jiaqi Bi Jianxiong Shen Chong Chen Zheng Li Haining Tan Peiyu Sun Youxi Lin |
| Institution: | 1. Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;2. Department of Spine Surgery, Orthopedics Center of Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China;3. Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Contribution: Formal analysis (lead), Project administration (equal), Resources (equal);4. Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Orthopedics, Bejing Hospital of Traditional Chinese Medicine, Beijing, China Contribution: Resources (equal), Software (equal);5. Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Contribution: Funding acquisition (equal), Supervision (equal), Validation (lead) |
| Abstract: | Melatonin is well-documented to have the ability of reducing nerve inflammation and scavenging free radicals. However, the therapeutic effect of melatonin on spinal cord injury has not been fully described. In this study, we assessed the effect of melatonin on T9 spinal cord injury established by Allen method in rats. Melatonin deficiency significantly delayed the recovery of sensory and motor functions in SCI rats. Treatment with melatonin significantly alleviated neuronal apoptosis and accelerated the recovery of spinal cord function. These results suggest that melatonin is effective to ameliorate spinal cord injury through inhibition of neuronal apoptosis and promotion of neuronal repair. |
| Keywords: | Luzindole melatonin PI3K-AKT1 pathway spinal cord injury |