|
|||||
|
|
Sirtuin 1 alleviates neuroinflammation-induced apoptosis after traumatic brain injury |
|
| Authors: | Guan Wei Jiawei Wang Yanbin Wu Xiaoxin Zheng Yile Zeng Yasong Li Xiangrong Chen |
| Affiliation: | 1. Department of Emergency, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China Contribution: Writing - original draft (equal);2. Department of Emergency, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China Contribution: Conceptualization (equal), Software (supporting);3. Department of Neurosurgery, Anxi County Hospital of Traditional Chinese Medicine, Quanzhou, China Contribution: Conceptualization (equal), Visualization (equal), Writing - review & editing (equal);4. Department of Neurosurgery, Anxi County Hospital of Traditional Chinese Medicine, Quanzhou, China Contribution: Investigation (equal), Writing - review & editing (equal);5. Department of Neurosurgery, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China Contribution: Data curation (equal), Methodology (supporting), Software (equal);6. Department of Neurosurgery, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China |
| Abstract: | Sirtuin 1 (SIRT1) plays a very important role in a wide range of biological responses, such as metabolism, inflammation and cell apoptosis. Changes in the levels of SIRT1 have been detected in the brain after traumatic brain injury (TBI). Further, SIRT1 has shown a neuroprotective effect in some models of neuronal death; however, its role and working mechanisms are not well understood in the model of TBI. This study aimed to address this issue. SIRT1-specific inhibitor (sirtinol) and activator (A3) were introduced to explore the role of SIRT1 in cell apoptosis. Results of the study suggest that SIRT1 plays an important role in neuronal apoptosis after TBI by inhibiting NF-κB, IL-6 and TNF-α deacetylation and the apoptotic pathway sequentially, possibly by alleviating neuroinflammation. |
| Keywords: | neuroinflammation neuronal apoptosis NF-κB sirtuin 1 traumatic brain injury |