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Circular RNA in colorectal cancer |
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| Authors: | Anthony Li Wei Cen Wang Vivian McAlister Qinfeng Zhou Xiufen Zheng |
| Institution: | 1. Department of Pathology and Laboratory Medicine, Western University, London, Canada
School of Medicine, Queen’s University, Kingston, Canada Contribution: Conceptualization (equal), Data curation (equal), Visualization (equal), Writing - original draft (equal), Writing - review & editing (equal);2. Department of Microbiology & Immunology, Western University, London, Canada Contribution: Conceptualization (equal), Data curation (equal), Visualization (equal), Writing - original draft (equal), Writing - review & editing (equal);3. Department of Surgery, Western University, London, Canada London Health Sciences Centre, London, Canada Contribution: Supervision (supporting), Writing - review & editing (equal);4. Department of Pathology and Laboratory Medicine, Western University, London, Canada Department of Laboratory Medicine, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China Contribution: Writing - review & editing (equal);5. Department of Pathology and Laboratory Medicine, Western University, London, Canada |
| Abstract: | Circular RNA (circRNA) is a highly abundant type of single-stranded non-coding RNA. Novel research has discovered many roles of circRNA in colorectal cancer (CRC) including proliferation, metastasis and apoptosis. Furthermore, circRNAs also play a role in the development of drug resistance and have unique associations with tumour size, staging and overall survival in CRC that lend circRNAs the potential to serve as diagnostic and prognostic biomarkers. Among cancers worldwide, CRC ranks second in mortality and third in incidence. In order to have a better understanding of the influence of circRNA on CRC development and progression, this review summarizes the role of specific circRNAs in CRC and evaluates their potential value as therapeutic targets and biomarkers for CRC. We aim to provide insight in the development of therapy and clinical decision-making. |
| Keywords: | biomarker circRNA colorectal cancer drug resistance therapeutic target |