|
|||||
|
|
The HIF-1α/p53/miRNA-34a/Klotho axis in retinal pigment epithelial cells promotes subretinal fibrosis and exacerbates choroidal neovascularization |
|
| Authors: | Laiqing Xie Ying Wang Quan Li Xiaoyan Ji Yuanyuan Tu Shu Du Hui Lou Xinwei Zeng Linling Zhu Ji Zhang Manhui Zhu |
| Institution: | 1. Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou, China
Contribution: Conceptualization (equal), ?Investigation (equal), Writing - original draft (equal);2. Department of Ophthalmology, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, China Contribution: Conceptualization (equal), Formal analysis (equal), ?Investigation (equal), Resources (equal), Supervision (equal);3. Center of Stomatology, The Second Affiliated Hospital of Soochow University, Suzhou, China Contribution: Data curation (equal), Formal analysis (equal), ?Investigation (equal), Methodology (equal), Resources (equal), Software (equal);4. Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou, China Contribution: Conceptualization (equal), ?Investigation (equal), Resources (equal), Validation (equal);5. Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, China Contribution: Conceptualization (equal), Data curation (equal), Resources (equal), Software (equal), Supervision (equal);6. Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, China Contribution: Conceptualization (equal), ?Investigation (equal), Visualization (equal);7. Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou, China Contribution: ?Investigation (equal), Resources (equal);8. Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, China Contribution: ?Investigation (equal), Methodology (equal), Resources (equal);9. Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou, China;10. Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, China |
| Abstract: | |
| Keywords: | choroidal neovascularization hypoxia-inducible factor-1α (HIF-1α) Klotho microRNA-34a (miRNA-34a) p53 subretinal fibrosis |