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Combined inhibition of Ref-1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co-culture models |
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| Authors: | Rachel A Caston Fenil Shah Colton L Starcher Randall Wireman Olivia Babb Michelle Grimard Jack McGeown Lee Armstrong Yan Tong Roberto Pili Joseph Rupert Teresa A Zimmers Adily N Elmi Karen E Pollok Edward A Motea Mark R Kelley Melissa L Fishel |
| Institution: | 1. Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA
Contribution: Investigation (supporting), Writing - original draft (equal), Writing - review & editing (equal);2. Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA Contribution: Conceptualization (supporting), Data curation (supporting), Investigation (equal), Writing - review & editing (supporting);3. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA Contribution: Investigation (supporting), Writing - review & editing (supporting);4. Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA Contribution: Investigation (supporting), Methodology (supporting), Writing - review & editing (supporting);5. Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA Contribution: Data curation (supporting), Writing - review & editing (supporting);6. Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA Contribution: Investigation (supporting);7. Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA Contribution: Investigation (supporting), Writing - review & editing (supporting);8. Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA Contribution: Formal analysis (supporting), Investigation (supporting), Writing - review & editing (supporting);9. Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA Department of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN, USA Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA Contribution: Resources (supporting);10. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA Contribution: Investigation (supporting), Resources (supporting);11. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA Contribution: Conceptualization (equal), Resources (supporting), Supervision (supporting), Writing - review & editing (supporting);12. Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA Contribution: Resources (supporting), Writing - review & editing (supporting);13. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA Contribution: Supervision (supporting), Validation (supporting), Writing - review & editing (supporting);14. Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA Contribution: Conceptualization (equal), Funding acquisition (equal), Project administration (equal), Resources (lead), Supervision (equal), Writing - original draft (lead);15. Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA |
| Abstract: | |
| Keywords: | APE1/Ref-1 Cancer-associated fibroblasts Napabucasin Pancreatic cancer Ruxolitinib STAT3 tumor microenvironment |