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Association between non-alcoholic fatty liver disease with the susceptibility and outcome of COVID-19: A retrospective study |
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| Authors: | Guyi Wang Shangjie Wu Chenfang Wu Quan Zhang Fang Wu Bo Yu Siye Zhang Chao Wu Guobao Wu Yanjun Zhong |
| Affiliation: | 1. Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Project administration (equal), Resources (equal), Writing - original draft (equal), Writing - review & editing (equal);2. Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China Contribution: Funding acquisition (equal), Investigation (equal), Supervision (equal), Validation (equal), Writing - review & editing (equal);3. Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China Contribution: Data curation (equal), Investigation (equal), Supervision (equal), Writing - review & editing (equal);4. Critical Care Medicine, The First Hospital of Changsha, China Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Resources (equal);5. Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China Contribution: Formal analysis (equal), Investigation (equal), Supervision (equal), Writing - review & editing (equal);6. Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China Contribution: Conceptualization (equal), Data curation (equal), Methodology (equal);7. Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China Contribution: Data curation (equal), Formal analysis (equal), Methodology (equal);8. Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China Contribution: Data curation (equal), Formal analysis (equal), Writing - original draft (equal);9. Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China Contribution: Supervision (equal), Writing - review & editing (equal);10. Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China |
| Abstract: | This study aims to evaluate the effect of non-alcoholic fatty liver disease (NAFLD) on the susceptibility and consequences of coronavirus disease 2019 (COVID-19). We retrospectively collected data from 218 adult COVID-19 patients who showed no evidence of excessive alcohol consumption and underwent abdominal ultrasound examinations. Of these patients, 39.4% patients had been diagnosed with NAFLD, which indicates a much higher prevalence of NAFLD than that reported in the general population. Significantly elevated white blood cell count (p = 0.008), alanine aminotransferase (p = 0.000), aspartate aminotransferase (p = 0.006) and C reactive protein (p = 0.012) were found in the patients with NAFLD. These patients also had significantly higher proportions of hypertension (p = 0.006) and diabetes (p = 0.049) than the non-NAFLD cases. No significant differences existed in the severity, mortality, viral shedding time and length of hospital stay between patients with or without NAFLD in the sample population. However, subgroup analyses found that in patients with normal body mass index (BMI), NAFLD sufferers were more likely to experience a severe event (30.0% vs 11.5%, p = 0.021). Kaplan-Meier curve (log-rank p = 0.017) and Cox regression (HR = 3.26, 95% CI: 1.17–9.04, p = 0.023) analyses confirmed that before and after adjusting for gender, age and comorbidities, NAFLD patients with normal BMI had a higher incidence of suffering severe events. People with NAFLD may have a higher proportion of COVID-19. NAFLD may be correlated with the severity of COVID-19 patients in the normal BMI group. |
| Keywords: | body mass index COVID-19 liver injury non-alcoholic fatty liver disease outcome susceptibility |