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Selenoprotein P and Yunnan Endemic Sudden Cardiac Death—an Ecological Study |
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| Authors: | Q Li X Z Li T Wang L W Zhou H Q Feng L Gao J R Pei C Lin C X Jiang |
| Institution: | 1. Institute of Keshan Disease, Center for Endemic Disease Control, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China 2. Harbin Medical University Cancer Hospital, Harbin, 150040, China 3. Department of Epidemiology, Jiamusi University, Jiamusi, 154007, China 4. National Key Laboratory of Molecular Oncology, Institute of Oncology, Union Medical College, Beijing, 100021, China 5. Department of Finance, Ministry of Health, 1 Xizhimengwai Nanlu, Beijing, 100044, China |
| Abstract: | The aim of the present study was to explore the role of selenoprotein P (SePP) in the etiology of the endemic sudden cardiac death in Yunnan, China. The levels of SePP of 124 subjects and glutathione peroxidase (GPx) of 119 subjects were measured. The subjects were from the old and new endemic areas and non-endemic areas. The levels of SePP and GPx of the subjects of the old endemic area were significantly higher than those of the subjects of the new endemic area and the non-endemic areas, respectively. The Pearson’s correlation among SePP, GPx, and the number of the incident cases of the disease were statistically significant. These correlations show that there is an inverse relationship among the number of patients and the levels of SePP (r? = ?? 0.9800, P ?= ?0.0200) and GPx (r? = ?? 0.961, P ?= ?0.009). The results show that selenium deficiency might play an important role in the incidence of the disease. |
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