SNAP-25 inhibits L-type Ca2+ channels in feline esophagus smooth muscle cells |
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Authors: | Ji Junzhi Muinuddin Ahmad Kang Youhou Diamant Nicholas E Gaisano Herbert Y |
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Institution: | University Health Network, Toronto Western Hospital, Ont., M5T 2S8, Toronto, Canada. |
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Abstract: | We recently reported that non-secretory gastrointestinal smooth muscle cells also possessed SNARE proteins, of which SNAP-25 regulated Ca(2+)-activated (K(Ca)) and delayed rectifier K(+) channels (K(V)). Voltage-gated, long lasting (L-type) calcium channels (L(Ca)) play an important role in excitation-contraction coupling of smooth muscle. Here, we show that SNAP-25 could also directly inhibit the L-type Ca(2+) channels in feline esophageal smooth muscle cells at the SNARE complex binding synprint site. SNARE proteins could therefore regulate additional cell actions other than membrane fusion and secretion, in particular, coordinated muscle membrane excitability and contraction, through their actions on membrane Ca(2+) and K(+) channels. |
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Keywords: | SNARE proteins SNAP-25 L-type calcium channel Smooth muscle Esophagus Feline Peristalsis |
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