Incorporation of [14C]histidine into homocarnosine and carnosine of frog brain in vivo and in vitro |
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| Authors: | William C Yockey and Finley D Marshall |
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| Institution: | Department of Biochemistry, University of South Dakota, Vermillion, S. Dak. 57069, U.S.A. |
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| Abstract: | 1. Homocarnosine, carnosine and histidine were determined in brain from several species and the results compared with values in the literature. 2. (14)C]Homocarnosine and (14)C]carnosine were isolated from frog brain after intracerebral injection of (14)C]histidine in vivo. 3. Whole frog brain, incubated in vitro with l-(14)C]histidine, formed labelled homocarnosine and carnosine. 4. A frog brain homogenate or supernatant fraction catalysed the incorporation of l-(14)C]histidine into homocarnosine and carnosine. 5. The results indicate that brain tissue can synthesize homocarnosine and carnosine. |
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