Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham |
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| Authors: | Gallo Margareth B C Marques Anna Sylvia F Vieira Paulo C da Silva Maria Fátima das G F Fernandes João B Silva Márcio Guido Rafael V Oliva Glaucius Thiemann Otávio H Albuquerque Sérgio Fairlamb Alan H |
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| Affiliation: | Departamento de Química, Universidade Federal de S?o Carlos, CP 676, 13565-905, S?o Carlos-SP, Brazil. margareth.gallo@gmail.com |
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| Abstract: | Hexanic, methanolic, and hydroalcoholic extracts, and 34 isolated compounds from Vitex polygama Cham. (Lamiaceae, formely Verbenaceae) and Siphoneugena densiflora O. Berg (Myrtaceae) were screened for their trypanocidal effects on bloodstream forms of Trypanosoma cruzi and T brucei, as well as for their enzymatic inhibitory activities on glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) and trypanothione reductase (TR) enzymes from T cruzi and adeninephosphoribosyl transferase (APRT) enzyme from Leishmania tarentolae. In general, polar extracts displayed strong effects and some of the tested compounds have shown good results in comparison to positive controls of the bioassays. |
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