In Vitro and In Vivo Investigation of Drug-Eluting Implants for the Treatment of Periodontal Disease |
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| Authors: | Fu-Ying Lee Dave W. Chen Chih-Chien Hu Yu-Te Hsieh Shih-Jung Liu Err-Cheng Chan |
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| Affiliation: | (1) Department of Periodontics, Division of Dentistry, Chang Gung Memorial Hospital, Taoyuan, Taiwan;(2) Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan;(3) College of Medicine, Chang Gung University, Taoyuan, Taiwan;(4) Department of Mechanical Engineering, Chang Gung University, Taoyuan, Taiwan;(5) School of Medical Technology, Chang Gung University, Taoyuan, Taiwan;(6) Biomaterials Laboratory, Mechanical Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 333, Taiwan; |
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| Abstract: | ![]()
This paper developed solvent-free drug-eluting implants for metronidazole delivery for the treatment of periodontal disease and investigated the characteristics of the drug’s release from the implants, both in vitro and in vivo, using an HPLC assay. The metronidazole exhibited a two-stage release behavior in vitro with an initial burst release followed by a diffusion-controlled release and then a secondary burst release. The accumulated drug release reached 100% on the 18th day, and the drug-eluting implant was totally dissolved on the same day. Additionally, the drug-eluting disks were implanted within the sub-gingival space of both lower incisors of six rabbits. The curve of in vivo drug release was smoother and showed a predominantly diffusion-controlled release. The implants were totally dissolved at 2 weeks after implantation. The concentration of metronidazole remained above the MIC90 during the entire investigation. |
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