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Addressing the malaria drug resistance challenge using flow cytometry to discover new antimalarials |
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| Authors: | Brian T. Grimberg Maria M. Jaworska Lindsay B. Hough Peter A. Zimmerman James G. Phillips |
| Affiliation: | aCenter for Global Health & Diseases, Case Western Reserve University, Cleveland, OH 44106-7286, USA;bCurragh Chemistries Inc., c/o Sherwin-Williams Cradle, Valley View, OH 44125, USA;cCenter for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA |
| Abstract: | A new flow cytometry method that uses an optimized DNA and RNA staining strategy to monitor the growth and development of the Plasmodium falciparum strain W2mef has been used in a pilot study and has identified Bay 43-9006 1, SU 11274 2, and TMC 125 5 as compounds that exhibit potent (<1 μM) overall and ring stage in vitro antimalarial activity. |
| Keywords: | Cytometry Malarial Drug discovery |
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