HOXA13 and HOXD13 expression during development of the syndactylous digits in the marsupial Macropus eugenii |
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| Authors: | Keng Yih Chew Hongshi Yu Andrew J Pask Geoffrey Shaw and Marilyn B Renfree |
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| Institution: | (1) ARC Centre of Excellence in Kangaroo Genomics, The University of Melbourne, Melbourne, Victoria, 3010, Australia;(2) Department of Zoology, The University of Melbourne, Melbourne, Victoria, 3010, Australia;(3) Department of Molecular and Cellular Biology, The University of Connecticut, Storrs, CT 06269, USA |
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| Abstract: | Background Kangaroos and wallabies have specialised limbs that allow for their hopping mode of locomotion. The hindlimbs differentiate
much later in development but become much larger than the forelimbs. The hindlimb autopod has only four digits, the fourth
of which is greatly elongated, while digits two and three are syndactylous. We investigated the expression of two genes, HOXA13 and HOXD13, that are crucial for digit patterning in mice during formation of the limbs of the tammar wallaby. |
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