A complex balanced chromosomal rearrangement in repeated abortions |
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| Authors: | Alberto Barros M Carmo Tavares Sérgio Castedo M Salomé Pereira M Purificação Tavares M Almeida e Costa |
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| Institution: | (1) Department of Medical Genetics, Faculty of Medicine, University of Porto, P-4200 Porto, Portugal;(2) Júlio Dinis Maternity Hospital, Oporto, Portugal |
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| Abstract: | Summary A double balanced reciprocal translocation involving four chromosomes, t(1;19;6;14) (1p11; 19p11; 6q25; 14q21), was found in the phenotypically normal husband in a couple referred because of repeated abortions. Reciprocal translocations, t(6;14), had been transmitted by his mother, his father being apparently homozygous for a translocation comprising pairs 1 and 19-t(1;19)(1;19). The genetic consequences of this complex chromosomal rearrangement are analyzed. |
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