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Effect of Quinolinic Acid in the Nucleus Basalis Magnocellularis on Cortical High-Affinity Choline Uptake |
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| Authors: | R. H. Metcalf R. J. Boegman R. Quirion R. J. Riopelle S. K. Ludwin |
| Affiliation: | Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada;Douglas Hospital Research Center and Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada;Department of Medicine, Queen's University, Kingston, Ontario, Canada;Department of Pathology, Queen's University, Kingston, Ontario, Canada |
| Abstract: | A transient 45% increase in cortical high-affinity choline uptake (HACU) was observed after an injection of quinolinic acid (QUIN) into the nucleus basalis magnocellularis (nbM) of the rat. This was followed by a steady decline in choline uptake, which resulted in a 46% decrease by day 7. Specific [3H]hemicholinium-3 binding to coronal brain sections showed a similar pattern following injections of QUIN into the nbM. The increase in cortical HACU elicited by QUIN appeared to be dose dependent. |
| Keywords: | High-affinity choline uptake Hemicholinium binding Quinolinic acid Nucleus basalis magnocellularis Cortex |