| 抑癌基因D L C-1 的研究进展 |
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| 引用本文： | 金月玲 伍健 黄培林. 抑癌基因D L C-1 的研究进展[J]. 现代生物医学进展, 2006, 6(11): 102-104 |
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| 作者姓名： | 金月玲 伍健 黄培林 |
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| 作者单位： | 东南大学基础医学院病理学系,江苏,南京,210009 |
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| 摘 要： | DLC-1（frequently deletedin liver cancer）基因是新发现的一个肿瘤抑制基因。它的失活有可能参与肿瘤的发生和发展。本文拟就DLC-1基因的结构功能及其在遗传和表遗传方面的失活机制作一综述。
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| 关 键 词： | 抑癌基因 DLC-1 遗传 表遗传 |
| 收稿时间： | 2006-08-10 |
| 修稿时间： | 2006-09-20 |
Research progress on DLC-1, a candidate tumor suppressor gene |
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| JIN Yue-Ling,WU Jian,HUANG Pei-Lin. Research progress on DLC-1, a candidate tumor suppressor gene[J]. Progress in Modern Biomedicine, 2006, 6(11): 102-104 |
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| Authors: | JIN Yue-Ling WU Jian HUANG Pei-Lin |
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| Abstract: | DLC-1 (frequently deleted in liver cancer) is located on chromosome 8p21-22, isolated from a primary human hepatocellular carcinoma (HCC). Inactivation and aberrant expression of DLC-1 gene may be caused by genomic deletion, promoter hypermethylation or mutation. .In this paper,the genetics and phenogenerics,structure and functions of DLC-1 gene were reviewed. |
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| Keywords: | DLC-1 Genetics Phenogenetics |
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