An effective approach for identification of in vivo protein-DNA binding sites from paired-end ChIP-Seq data |
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| Authors: | Congmao Wang Jie Xu Dasheng Zhang Zoe A Wilson Dabing Zhang |
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| Affiliation: | (1) School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China;(2) School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, UK;(3) Bio-X Research Center, Key Laboratory of Genetics & Development and Neuropsychiatric Diseases, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200240, China |
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| Abstract: | Background ChIP-Seq, which combines chromatin immunoprecipitation (ChIP) with high-throughput massively parallel sequencing, is increasingly being used for identification of protein-DNA interactions in vivo in the genome. However, to maximize the effectiveness of data analysis of such sequences requires the development of new algorithms that are able to accurately predict DNA-protein binding sites. |
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