Developmental effects of monensin on Drosophila melanogaster |
| |
Authors: | Patrick Callaerts Arnold De Loof |
| |
Institution: | (1) Zoological Institute, Katholieke Universiteit Leuven, Naamsestraat 59, B-3000 Leuven, Belgium;(2) Biocentrum, Klingelbergstrasse 70, CH-4056 Basel, Switzerland |
| |
Abstract: | Extracellular matrix and membrane proteins and their correct secretion probably are key elements in morphogenesis and differentiation in Drosophila. In this study, we have analysed the effects of monensin, a Na+-H+-ionophore which blocks normal secretion, applied during cellular blastoderm formation on further development. Normal cell morphology and intercellular contacts are lost and the extracellular matrix becomes disorganized. Gastrulation is blocked and abnormal foldings can be observed. Cuticle phenotypes showed different degrees of ventral, dorsal, head and posterior defects. The results are discussed in the context of what is known about membrane and extracellular matrix proteins in Drosophila. |
| |
Keywords: | Drosophila Monensin Extracellular matrix Membrane proteins Morphogenesis |
本文献已被 SpringerLink 等数据库收录! |
|