| 抗凋亡蛋白Mcl-1及其抑制剂的研究进展 |
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| 引用本文： | 赵廷丽,刘 阳,李征征,王 来,孙 立,袁胜涛.抗凋亡蛋白Mcl-1及其抑制剂的研究进展[J].现代生物医学进展,2019,19(6):1184-1187. |
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| 作者姓名： | 赵廷丽 刘 阳 李征征 王 来 孙 立 袁胜涛 |
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| 作者单位： | 中国药科大学江苏省新药筛选中心 |
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| 基金项目： | 国家自然科学基金项目（81773766） |
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| 摘 要： | 骨髓细胞白血病蛋白Mcl-1是Bcl-2家族蛋白中重要的抗凋亡蛋白成员,其在多种恶性肿瘤(急性细胞性白血病、多发性骨髓瘤等)中都具有高表达的特点,导致肿瘤细胞对传统化疗药物及Bcl-2抑制剂产生耐药性。Mcl-1作为抗肿瘤药物研发的重要靶点正日益受到相关研究人员的关注,其中Mcl-1新型抑制剂以及联合抑制剂的研究取得了较大进展。本文将对Mcl-1蛋白结构和功能以及相关抑制剂的研究做更深入的分析和总结。
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| 关 键 词： | Mcl-1蛋白 Bcl-2蛋白 抗凋亡 抑制剂 |
| 收稿时间： | 2018/4/30 0:00:00 |
| 修稿时间： | 2018/5/26 0:00:00 |
Research Progress of Anti-apoptotic Protein Mcl-1 and its Inhibitors |
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| ZHAO Ting-li,LIU Yang,LI Zheng-zheng,WANG Lai,SUN Li and YUAN Sheng-tao.Research Progress of Anti-apoptotic Protein Mcl-1 and its Inhibitors[J].Progress in Modern Biomedicine,2019,19(6):1184-1187. |
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| Authors: | ZHAO Ting-li LIU Yang LI Zheng-zheng WANG Lai SUN Li and YUAN Sheng-tao |
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| Institution: | China Medicine University, Jiangsu Center for New Drug Screening, Nanjing, Jiangsu, 210009, China,China Medicine University, Jiangsu Center for New Drug Screening, Nanjing, Jiangsu, 210009, China,China Medicine University, Jiangsu Center for New Drug Screening, Nanjing, Jiangsu, 210009, China,China Medicine University, Jiangsu Center for New Drug Screening, Nanjing, Jiangsu, 210009, China,China Medicine University, Jiangsu Center for New Drug Screening, Nanjing, Jiangsu, 210009, China and China Medicine University, Jiangsu Center for New Drug Screening, Nanjing, Jiangsu, 210009, China |
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| Abstract: | ABSTRACT: Bone marrow cell leukemia protein Mcl-1 is an important member of the anti-apoptotic protein in the Bcl-2 family protein, and has high expression in many kinds of malignant tumor (acute cell leukemia, multiple myeloma, etc), resulting in drug resistance to traditional chemotherapeutic agents and Bcl-2 inhibitors. As an important target for the research and development of antitumor drugs, Mcl-1 is increasingly concerned by the researchers. Great progress has been made in the research of new Mcl-1 inhibitors and joint inhibitors. This article will make a more in-depth analysis of the structure and function of Mcl-1 protein and related inhibitors, and results of the study will be of great significance for the treatment of cancer. |
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| Keywords: | Mcl-1 protein Bcl-2 protein Anti apoptosis Inhibitor |
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