血小板升高与妇科恶性肿瘤的影响

血小板升高与多种实体肿瘤的发生发展密切相关,研究表明14%-38%的恶性肿瘤患者伴有血小板升高。虽然目前国内外学者对于定义血小板升高的具体标准尚未完全统一,但大致范围在血小板计数大于220-400×109/L。大量的临床研究证实恶性肿瘤细胞可以分泌多种生长因子及细胞因子促进血小板升高,而升高的血小板又产生促进肿瘤细胞增殖、血管生长及转移的细胞因子。回顾相关文献在许多妇科恶性肿瘤研究中,除外阴癌外,治疗前的血小板升高多与疾病预后不良有关,由于血小板升高可以通过阻断血栓形成细胞因子来预防,因此对其评估在未来可能具有治疗意义。本文将就妇科恶性肿瘤与血小板升高的具体关联性进行探究。

Effect of Elevated Platelet Count on Gynecologic Malignancies

ABSTRACT: The increase of platelet is closely related to the development of multiple solid tumors, and studies show that between 14% and 38% of malignant tumors are associated with elevated platelets. Although scholars at home and abroad are not yet fully unified in the specific criteria for the definition of platelet elevation, the general range of platelet counts is greater than 220-400×10⁹/ L. A large number of clinical studies have confirmed malignant tumor cells can secrete a variety of cytokines and growth factors to promote thrombocytosis, and increased platelet and promote tumor cell proliferation, cell growth and metastasis of the tumor blood essels and factor. Review of relevant literature in the study of many gynecologic malignant tumors, except vulval cancer treatment before the increased platelet related to prognosis of disease, more because of the increased platelet can prevent thrombosis by blocking cytokines, thus to evaluate the possible therapeutic significance in the future. This paper will explore the specific correlation between gynecological malignant tumor and platelet.