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Differentiation of Pluripotent Embryonic Stem Cells in the Peritoneal Cavity of Irradiated Mice |
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| Authors: | O. F. Gordeeva E. S. Manuilova O. V. Payushina T. M. Nikonova I. A. Grivennikov N. G. Khrushchov |
| Affiliation: | (1) Russian Academy of Sciences, Kol'tsov Institute of Developmental Biology, ul. Vavilova 26, Moscow, 119808, Russia;(2) Russian Academy of Sciences, Institute of Molecular Genetics, pl. Akademika Kurchatova 2, Moscow, 123182, Russia |
| Abstract: | We studied the behavior and differentiation of pluripotent embryonic stem cells of R1 mice in vivo. Undifferentiated embryonic stem cells and differentiating embryoid bodies implanted in the abdominal cavity of irradiated mice were shown to form tumors containing the derivatives of all germ layers. Cells of the embryoid bodies form tumors two weeks after implantation, while undifferentiated embryonic stem cells form tumors only by week three. |
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