| 泛素与自噬 |
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| 引用本文： | 冯梅,王莉新,王易.泛素与自噬[J].国外医学：分子生物学分册,2011(4):349-354. |
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| 作者姓名： | 冯梅 王莉新 王易 |
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| 作者单位： | 上海中医药大学免疫学与病原生物学教研室,上海市201203 |
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| 基金项目： | 上海市教育委员会重点学科建设项目（No.J50301）,上海高校选拔培养优秀青年教师科研专项基金（No.szy10002） |
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| 摘 要： | 泛素调节的蛋白质降解过程和细胞的自噬现象都是细胞自我调节的基本机制。其中，泛素可能作为一种普遍的识别信号参与了白噬过程；而自噬的诱导又能促进泛素化作用，从而增强对底物的降解。本文着重探讨这两者间的关系及可能存在的相互调节作用，并兼及两者共同涉及的细胞程序性死亡现象。
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| 关 键 词： | 泛素 自噬 程序性细胞死亡 |
Ubiquitin and Autophagy |
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| Authors: | FENG Mei WANG Lixin WANG Yi |
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| Institution: | (Department of Immunology and Pathogen Biology, Shanghai University of TCM, Shanghai 201203, China) |
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| Abstract: | Protein degradation mediated by ubiquitin and autophagy are the basic mechanisms involved in cellular self-regulation. Ubiquitin may be involved in the process of autophagy by serving as a universal recognition signal. Induction of autophagy can promote ubiquitination, thereby enhan- cing the degradation of substrate. This paper mainly focuses on the relation and the potential mutual regulation between ubiquitination and autophagy, as well as the phenomenon of programmed cell death that is associated with both ubiquitination and autophagy processes. |
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| Keywords: | ubiquitin autophagy programmed cell death （PCD） |
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