| 细胞P120的作用 |
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| 引用本文： | 秦灵芝[综述],王曦[审阅].细胞P120的作用[J].国外医学：分子生物学分册,2011(3):257-260. |
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| 作者姓名： | 秦灵芝[综述] 王曦[审阅] |
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| 作者单位： | 华中科技大学同济医学院附属同济医院病理学研究所,武汉市430030 |
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| 基金项目： | 国家自然科学基金（No.81070009） |
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| 摘 要： | P120属于连环蛋白家族成员,通常情况下,P120定位于细胞膜,通过钙黏附素介导细胞之间的黏附.当P120异位分布于细胞质和细胞核时,与细胞增殖、炎性反应及肿瘤的发生发展关系密切.文章综述了P120结构、亚型及P120在细胞的不同定位和作用.从分子生物学领域进一步阐明细胞P120的作用,为临床治疗疾病提供新的靶点.
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| 关 键 词： | P120蛋白 钙黏附素 细胞黏附 细胞增殖 |
P120 Protein and Its Cellular Function |
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| Institution: | QIN Lingzhi(Institute of Pathology, Tongji Hospital, Tongfi Medical College, Huazhong University of Science ＆ Technology, Wuhan, 430030, China) |
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| Abstract: | P120-catenin belongs to the Armadillo protein family. It is generally localized in the cell membrane, mediating cell-cell adhesion via cadherins. Ectopic expression of P120 in the cyto- plasm and nucleus is closely associated with cell proliferation, inflammatory responses and carcino- genesis. In this review, the structure and isoforms of P120, and its cellular localization and associ- ated different functions of P120 are introduced. Furthermore, molecular and biological functions of cellular PI20 are elucidated to provide the novel target for clinical treatment. |
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| Keywords: | P120 cadherins cell-cell adhesion cell proliferation |
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