| 热量限制对延缓衰老的作用 |
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| 引用本文： | 祝扬扬,宁斌,吴远双,宋玉竹,孟庆雄.热量限制对延缓衰老的作用[J].国外医学：分子生物学分册,2011(2):185-188. |
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| 作者姓名： | 祝扬扬 宁斌 吴远双 宋玉竹 孟庆雄 |
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| 作者单位： | 昆明理工大学白龙校区生命科学与技术学院,昆明市650224 |
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| 基金项目： | 国家自然科学基金（No.30760194,31000960） |
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| 摘 要： | 热量限制（caloric restriction,CR）在很多物种中能够改善健康和延缓衰老,近年来的许多研究发现,热量限制可以减少多种与年龄相关性疾病的发生,但至今热量限制延缓衰老的机制尚未十分清楚.最近有研究表明,热量限制延缓衰老的机制可能与营养调控、生殖滞育等过程有密切的关系,SIRT1、PGC-1α、AMPK、TOR等信号因子也因其在热量限制和营养调控延缓衰老的机制研究中的重要作用而受到极大的关注.
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| 关 键 词： | 热量限制 沉默信息调节因子1 过氧化物酶增殖体激活受体-γ辅助激活因子1 腺苷酸活化蛋白激酶 雷帕霉素靶蛋白 |
Caloric Restriction and Lifespan Extension |
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| Authors: | ZHU Yangyang NING Bin WU Yuanshuang SONG Yuzhu MENG Qingxiong |
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| Institution: | (Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650224, China) |
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| Abstract: | Caloric restriction （CR） improves health and extends lifespan in a variety of species. It has been found that CR can reduce the incidence a number of age-related diseases. However, how CR extends lifespan remains largely unclear. Recent studies suggest that the nutritional regulation and reproductive diapause may affect the process of lifespan extension by CR. In addition, the signaling factors SIRT1, PGC-1 α, AMPK and TOR have also draw attention because of their important role in CR processes. |
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| Keywords: | caloric restriction SIRT1 PGC-1α AMPK TOR |
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