Towards interbreed IBD fine mapping of the mh locus: Double-muscling in the Asturiana de los Valles breed involves the same locus as in the Belgian Blue cattle breed |
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| Authors: | S Dunner C Charlier F Farnir B Brouwers J Canon M Georges |
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| Institution: | (1) Laboratorio de Genetica, Dpto. de Produccion Animal, Universidad Complutense, 28040 Madrid, Spain, ES;(2) Department of Genetics, Faculty of Veterinary Medicine, University of Liège (B43), 20 Bd de Colonster, 4000-Liège, Belgium, BE |
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| Abstract: | The Spanish ``Asturiana' cattle breed is characterized by the segregation of a genetically determined muscular hypertrophy
referred to as double-muscling or ``culones'. We demonstrate by linkage analysis that this muscular hypertrophy involves
the mh locus previously shown to cause double-muscling in the Belgian Blue cattle breed, pointing towards locus homogeneity of this
trait across both breeds. Moreover, using a twopoint and multipoint maximum likelihood approach, we show that flanking microsatellite
markers are in linkage disequilibrium with the mh locus in both breeds albeit with different alleles. Finally, we discuss how allelic homogeneity across breeds might be exploited
to achieve efficient genetic fine-mapping of the mh locus.
Received: 13 September 1996 / Accepted: 20 January 1997 |
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