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Antibodies to Z DNA stabilized with polyarginine |
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| Authors: | A Niveleau B Roux V Adouard R Dante B Revet E Delain |
| Abstract: | The left-handed form of poly(dG-m5dC).poly(dG-m5dC) induced by heating the copolymer in the presence of magnesium and stabilized with polyarginine can be used to raise antibodies in rabbits. These antibodies are able to recognize the Z conformation of both methylated and nonmethylated forms of the copolymers. In the same experimental conditions, hypermethylated B DNA is not recognized by these antibodies. |
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