Effect of Acute and Chronic Administration of Methylphenidate on Mitochondrial Respiratory Chain in the Brain of Young Rats |
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| Authors: | Ana O Fagundes Maira R Aguiar Claudia S Aguiar Giselli Scaini Monique U Sachet Nayara M Bernhardt Gislaine T Rezin Samira S Valvassori João Quevedo Emilio L Streck |
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| Institution: | 1.Laboratório de Fisiopatologia Experimental, Programa de Pós-Gradua??o em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde,Universidade do Extremo Sul Catarinense,Criciúma,Brazil;2.Laboratório de Neurociências,Universidade do Extremo Sul Catarinense,Criciúma,Brazil |
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| Abstract: | Methylphenidate is commonly used for the treatment of attention deficit/hyperactivity disorder. There are still few works
regarding the effects of methylphenidate on brain energy metabolism. Thus, in the present study we evaluated the effect of
chronic administration of methylphenidate on the activities of mitochondrial respiratory chain complexes I and III in the
brain of young rats. The effect of acute administration of methylphenidate on mitochondrial respiratory chain complexes I,
II, III and IV in the brain of young rats was also investigated. For acute administration, a single injection of methylphenidate
was given to rats on postnatal day 25. For chronic administration, methylphenidate injections were given starting at postnatal
day 25 once daily for 28 days. Our results showed that complexes I and III were not affected by chronic administration of
methylphenidate. Moreover, the acute administration of methylphenidate decreased complex I activity in cerebellum and prefrontal
cortex, whereas complexes II, III and IV were not altered. |
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