Heterozygote frequencies in small subpopulations. |
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Authors: | G C Kirby |
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Institution: | Department of Genetics, University of Adelaide, Adelaide, South Australia, Australia |
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Abstract: | The mean fixation index within subpopulations (FIS) has been defined as . The latter definition is preferred because it can be obtained from the two other fixation indices, FST and FIT and because it is unaffected by the mean gene frequency. The expected frequency of heterozygotes in small subpopulations of dioecious organisms will exceed Hardy-Weinberg expectations and this can be measured by . In an isolated subpopulation of constant variance effective size rapidly tends to . In the Island model of population structure, is approximately is the immigration rate.When a sample is drawn from a natural population, the observed FIS will depend upon the genetic structure of the population. The values of FIS expected in three different types of population structure are discussed. |
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