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| 脑心通对急性低压低氧小鼠空间记忆功能及脑水肿的影响 | |
| 引用本文： | 薛婧,徐江涛,李景春. 脑心通对急性低压低氧小鼠空间记忆功能及脑水肿的影响[J]. 现代生物医学进展, 2010, 10(5) |
| 作者姓名： | 薛婧 徐江涛 李景春 |
| 作者单位： | 1. 石河子大学医学院,新疆,石河子,832002 2. 兰州军区乌鲁木齐总医院神经内科,新疆,乌鲁木齐,830000 |
| 摘 要： | 目的:探讨脑心通对急性低压低氧诱发的空间记忆功能损害及脑水肿的预防作用及机制。方法:144只小鼠随机分为6组:即常压常氧组、常压常氧给药组、模拟海拔4km组(4km组)、模拟海拔8km组(8km组)、模拟海拔4km给药组(4km给药组)、模拟海拔8km给药组(8km给药组)。比较各组实验前后及组间的Y型电迷宫测试成绩及脑组织水含量、伊文思兰(EB)含量。结果:各组实验前的Y型电迷宫训练成绩无显著差异,实验后常压常氧组、常压常氧给药组、4km组、4km给药组、8km组和8km给药组,Y型电迷宫测试成绩分别为90.00±6.32、93.33±5.16、56.67±8.16、86.67±8.16、45.00±10.49和85.00±5.48(P<0.01);常压常氧组、常压常氧给药组、4km组、4km给药组、8km组和8km给药组比较,脑组织水含量结果分别为77.79±0.27、77.66±0.23、78.42±0.18、77.81±0.18、79.04±0.33、77.94±0.42,EB含量结果分别为0.44±0.04、0.43±0.02、0.98±0.07、0.46±0.06、1.17±0.07、0.49±0... |
| 关 键 词： | 低压低氧 小鼠 电迷宫 脑水肿 |
The effect of Naoxintong on spatial memory function and cerebral edema of acute hypobaric hypoxia in rats |
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| XUE Jing,XU Jiang-tao,LI Jing-chun. The effect of Naoxintong on spatial memory function and cerebral edema of acute hypobaric hypoxia in rats[J]. Progress in Modern Biomedicine, 2010, 10(5) | |
| Authors: | XUE Jing XU Jiang-tao LI Jing-chun |
| Affiliation: | XUE Jing1,XU Jiang-tao2,LI Jing-chun3 (1.The Medical College of Shihezi University,Xinjiang Shihezi,832002,China,2.Department of Neurology,Urumqi General Hospital,Lanzhou Comm,,PLA,Xinjiang wulumuqi,830000,China) |
| Abstract: | Objective:To investigate the protection and mechanism of Naoxintong on spatial memory functional lesion and cerebral edema of acute hypoxic hypoxia in rats.Methods:144 rats were randomly divided into six groups,which were normoxic control team,medication administration normoxic control team,simulated plateau 4000m (4km group)and simulated plateau 8000m team(8km group),simulated plateau 4000m (4km medication administration group)and simulated plateau 8000m medication administration team (8km medication admin... |
| Keywords: | hypoxic hypoxia rats electric maze test cerebral edema |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |