Intermittent maltose feeding enhances paclitaxel production in suspension culture of Taxus chinensis cells |
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| Authors: | Hyung-Kyoon Choi Sang-Ic Kim Joo-Sun Son Seung-Suh Hong Hyun-Soo Lee In-Sik Chung Hyong-Joo Lee |
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| Institution: | (1) Samyang Genex Biotech Research Institute, Taejon, 305-348, Korea;(2) Department of Genetic Engineering, Kyung Hee University, Suwon, 449-701, Korea;(3) Department of Food Science and Technology, School of Agricultural Biotechnology, Seoul National University, Suwon, 441-100, Korea |
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| Abstract: | High paclitaxel production (26 mg l–1) was achieved through the intermittent feeding of 3, 1, and 2% (w/v) sucrose at days 0, 7, and 21, respectively, to a suspension culture of Taxus chinensis cells. Intermittent feedings of 1 and 2% (w/v) maltose at days 7 and 21, respectively, to the culture increased the paclitaxel production up to 67 mg l–1. |
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| Keywords: | intermittent feeding maltose paclitaxel Taxus chinensis |
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