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The role of neisserial Opa proteins in interactions with host cells |
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| Authors: | Dehio C Gray-Owen S D Meyer T F |
| Affiliation: | a Dept Infektionsbiologie, Max-Planck-Institut für Biologie, Spemannstraße 34, D-72076 Tübingen, Germany b T.F. Meyer is also in the Dept Molekulare Biologie, Max-Planck-Institut für Infektionsbiologie, Monbijoustr. 2, D-10117 Berlin, Germany. |
| Abstract: | Pathogenic Neisseria spp. possess a repertoire of phase-variable Opa proteins that mediate various pathogen–host cell interactions, including bacterial engulfment by epithelial cells and opsonin-independent phagocytosis by professional phagocytes. Recent studies have identified cellular targets recognized by defined Opa proteins and have begun to reveal host signalling events involved in mediating these Opa-dependent cellular processes. |
| Keywords: | neisseria outer membrane protein adhesin receptor |
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