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Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED
Affiliation:1. Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, 727 East Tyler Street, Tempe, AZ 85287, USA;2. School of Molecular Sciences, Arizona State University, 551 East University Drive, Tempe, AZ 85287, USA;3. School for Engineering of Matter, Transport and Energy, Arizona State University, Tempe, AZ, USA;4. Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA;5. Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA;6. Departments of Biological Chemistry and Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Abstract:
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  • Keywords:lipidic cubic phase (LCP)  microcrystal electron diffraction (MicroED)  microcrystallography  additive phase conversion  lipase hydrolysis  Proteinase K  cholesterol  GPCR  membrane protein  cryo-electron microscopy (cryo-EM)
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