Design,synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

按检索

Design,synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis

Institution:	1. Department of Bio-resources and Food Science, Konkuk University, Seoul 143-701, Republic of Korea;2. Department of Biochemistry, Government Arts and Science College (Autonomous), Kumbakonam 612001, India;3. Department of Cell Biology, State University of New York (SUNY), Downstate Medical Center, College of Medicine, Brooklyn, NY 11203, USA;4. Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Biomedical Campus, 32 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyenggi-do, Republic of Korea;5. Department of Food Science and Biotechnology, Dongguk University-Seoul, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-820, Republic of Korea

Abstract:	Structural modification of active natural compounds which were originated from Traditional Chinese Medicine (TCM) have showed great advantages in the development of new drugs. In TCM, “Huangqin - Huanglian” is a classic “medicine couple” that has been used to treat intestinal diseases for thousands of years, while baicalin and berberine are the major active compounds of Huangqin and Huanglian respectively. Based on this “medicine couple”, we designed and synthesized a new baicalin and berberine hybrid compound (BBH). Its molecular structure was confirmed by spectroscopy. The antibacterial activity of BBH was detected in vitro. Results indicated that the new hybrid compound exhibited the best antibacterial activity for proteobacteria as compared with its original synthetic materials (baicalin and berberine). In vivo, the effect of BBH on ulcerative colitis was also investigated. BBH treatment significantly ameliorated the disease symptoms and prevented the colon damage of ulcerative colitis. Furthermore, BBH showed a significant anti-inflammatory effect through regulating activities of SOD, MPO and expressions of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) in colon tissue. Data also suggested that BBH was more superior than baicalin and berberine in ameliorating colonic damage. This indicated that the new hybrid compound BBH showed enhanced efficacy in treating ulcerative colitis.

Keywords:	Hybrid compound Medicine couple Traditional Chinese medicine Ulcerative colitis Inflammation TCM"} {"#name":"keyword" "$":{"id":"k0035"} "$$":[{"#name":"text" "_":"Traditional Chinese Medicine BBH"} {"#name":"keyword" "$":{"id":"k0045"} "$$":[{"#name":"text" "_":"baicalin and berberine hybrid compound UC"} {"#name":"keyword" "$":{"id":"k0055"} "$$":[{"#name":"text" "_":"ulcerative colitis IBD"} {"#name":"keyword" "$":{"id":"k0065"} "$$":[{"#name":"text" "_":"inflammatory bowel disease ROS"} {"#name":"keyword" "$":{"id":"k0075"} "$$":[{"#name":"text" "_":"reactive oxygen species SOD"} {"#name":"keyword" "$":{"id":"k0085"} "$$":[{"#name":"text" "_":"superoxide dismutase MPO"} {"#name":"keyword" "$":{"id":"k0095"} "$$":[{"#name":"text" "_":"myeloperoxidase IL-1β"} {"#name":"keyword" "$":{"id":"k0105"} "$$":[{"#name":"text" "_":"interleukin - 1β IL – 6"} {"#name":"keyword" "$":{"id":"k0115"} "$$":[{"#name":"text" "_":"interleukin - 6 TNF – α"} {"#name":"keyword" "$":{"id":"k0125"} "$$":[{"#name":"text" "_":"tumor necrosis factor - alpha
本文献已被 ScienceDirect 等数据库收录！

设为首页 | 免责声明 | 关于勤云 | 加入收藏