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Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors |
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| Authors: | Zbinden Katrin Groebke Obst-Sander Ulrike Hilpert Kurt Kühne Holger Banner David W Böhm Hans-Joachim Stahl Martin Ackermann Jean Alig Leo Weber Lutz Wessel Hans Peter Riederer Markus A Tschopp Thomas B Lavé Thierry |
| Affiliation: | F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland. katrin.groebke_zbinden@roche.com |
| Abstract: | We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway. |
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