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Antisense oligonucleotide inhibition of hepatitis C virus genotype 4 replication in HepG2 cells |
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| Authors: | Mostafa K El Awady Noha G Badr El Din Wael T El Garf Samar S Youssef Moataza H Omran Jasmin El Abd Said A Goueli |
| Affiliation: | (1) Department of Biomedical Technology, National Research Center, Dokki;(2) Research and Development, Promega Corp, University of Wisconsin, Madison, USA;(3) Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, USA |
| Abstract: | BackgroundHepatitis C (HCV) viral infection is a serious medical problem in Egypt and it has a devastating impact on the Egyptian economy. It is estimated that over 15% of Egyptians are infected by the virus and thus finding a cure for this disease is of utmost importance. Current therapies for hepatitis C virus (HCV) genotype 4 with interferon/ribavirin have not been successful and thus the development of alternative therapy for this genotype is disparately needed. |
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