Hydroxyapatite from Cuttlefish Bone: Isolation,Characterizations, and Applications |
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Authors: | Jayachandran Venkatesan P D Rekha Sukumaran Anil Ira Bhatnagar P N Sudha Chutiwan Dechsakulwatana Se-Kwon Kim Min Suk Shim |
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Institution: | 1.Yenepoya Research Center,Yenepoya (Deemed to be University), Deralakatte,Mangalore,India;2.Division of Bioengineering,Incheon National University,Incheon,Korea;3.Department of Periodontics, Saveetha Dental College and Hospitals,Saveetha University,Chennai,India;4.CSIR-Center for Cellular and Molecular Biology, Clinical Research Facility,Medical Biotechnology Complex,Hyderabad,India;5.Department of Chemistry,D.K.M. College for Women,Vellore,India;6.Institute of Marine Science,Burapha University,Muang Chonburi District,Thailand;7.Department of Marine Life Sciences,Korean Maritime and Ocean University,Busan,Korea |
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Abstract: | Hydroxyapatite (HA), a bioceramic, is a widely utilized material for bone tissue repair and regeneration because of its excellent properties such as biocompatibility, exceptional mechanical strength, and osteoconductivity. HA can be obtained by both synthetic and natural means. Animal bones are often considered a promising natural resource for the preparation of pure HA for biological and biomedical applications. Cuttlefish bone, also called as cuttlebone, mainly consists of calcium carbonate, and pure HA can be produced by adding phosphoric acid or ammonium hydrogen phosphate to it. Recently, cuttlefish bone-derived HA has shown promising results in terms of bone tissue repair and regeneration. The synthesized cuttlefish bone-derived has shown excellent biocompatibility, cell proliferation, increased alkaline phosphate activity, and efficient biomineralization ability with mesenchymal stem cells and osteoblastic cells. To further improve the biological properties of cuttlefish bone-derived HA, bioglass, polycaprolactone, and polyvinyl alcohol were added to it, which gave better results in terms of cell proliferation and osteogenic differentiation. Cuttlefish bone-derived HA with polymeric substances provides excellent bone formation under in vivo conditions. The studies indicate that cuttlefish bone-derived HA, along with polymeric and, protein materials, will be promising biomaterials in the field of bone tissue regeneration. |
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