Accumulation of heme in mitochondria from rabbit reticulocytes with inhibited globin synthesis |
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| Authors: | P&#x;emysl Po&#x;ka Jitka Borov Jan Neuwirt |
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| Institution: | Department of Pathological Physiology, Faculty of General Medicine, Charles University, Prague Czechoslovakia |
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| Abstract: | Incubation of rabbit reticulocytes with cycloheximide and 59Fe bound to transferrin in plasma induces excessive non-hemoglobin 59Fe-labeled heme accumulation in mitochondria. During incubation of these mitochondria in vitro a part of 59Fe-labeled heme is released into the surrounding medium. The addition of globin or bovine serum albumin to the incubation mixture essentially increases the amount of heme released from mitochondria. |
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