Anti-inflammatory neolignans from the roots of Magnolia officinalis |
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| Affiliation: | 1. School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan, ROC;2. Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan, ROC;3. Department of Medical Technology, Chung Hua University of Medical Technology, Tainan 717, Taiwan, ROC;4. Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan, ROC;5. Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan, ROC;6. Department of Pharmacy, Tajen University, Pintung 907, Taiwan, ROC;7. Department of Surgery, and Institute of Biomedical Engineering, National Cheng Kung University, Medical Center and Medical School, Tainan 701, Taiwan, ROC;8. Department of Anesthesiology, and Institute of Biomedical Engineering, National Cheng Kung University, Medical Center and Medical School, Tainan 701, Taiwan, ROC;9. Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA;10. Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 401, Taiwan, ROC;1. Nutrition and Toxicology Division, Federal Institute of Industrial Research, Lagos, Nigeria;2. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan;3. Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, (Westville Campus), Durban 4000, South Africa;4. Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi75270, Pakistan;5. Faculty of Medicine, University of Tabuk, P.O. Box 741, Tabuk 71491, Saudi Arabia;6. Structural Bioinformatics Group, Institute for Physiology & ECRC Charité – University Medicine Berlin, Berlin, Germany;7. Department of Chemistry, University of Ilorin, Ilorin, Nigeria;8. Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria;1. Royal Botanic Gardens, Kew, Richmond, Surrey TW9 3AB, UK;2. Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK;3. Natural History Museum Denmark, Solvgade 83, DK-1307 Copenhagen, Denmark;1. Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, HarBin Medical University, HarBin, 150081, People’s Republic of China;2. First affiliated hospital, Hei Long Jiang University of Chinese Medicine, HarBin, 150040, People’s Republic of China;3. College of Pharmacy, HarBin University of Commerce, HarBin, 150076, People’s Republic of China;1. Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea;2. Seoul Center, Korea Basic Science Institute (KBSI), Seoul 02841, Republic of Korea;3. Department of Culinary Art & Food Service Management, Yuhan University, Bucheon 14780, Republic of Korea;1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, People''s Republic of China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People''s Republic of China;3. University of Chinese Academy of Sciences, Beijing 100049, People''s Republic of China |
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| Abstract: | ![]()
Nine neolignan derivatives (1–9) were characterized from the roots of Magnolia officinalis, and their structures were elucidated based on spectroscopic and physicochemical analyses. Among them, houpulins E (1) and M (9) possess novel homo- and trinor-neolignan skeletons. In addition, 15 known compounds (10–24) were identified by comparison of their spectroscopic and physical data with those reported in the literature. Some of the purified constituents were examined for anti-inflammatory activity and, among the tested compounds, houpulins G (3), I (5), J (6), and 2,2′-dihydroxy-3-methoxy-5,5′-di-(2-propenylbiphenyl) (19) significantly inhibited superoxide anion generation and elastase release with IC50 values ranging from 3.54 to 5.48 μM and 2.16 to 3.39 μM, respectively. Therefore, these neolignan derivatives have tremendous potential to be explored as anti-inflammatory agents. |
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| Keywords: | Neolignans Anti-inflammatory activity Houpulins E–M |
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