An improved neutron autoradiography set-up for 10B concentration measurements in biological samples |
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| Authors: | Ian Postuma Silva Bortolussi Nicoletta Protti Francesca Ballarini Piero Bruschi Laura Ciani Sandra Ristori Luigi Panza Cinzia Ferrari Laura Cansolino Saverio Altieri |
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| Institution: | aDepartment of Physics, University of Pavia, Italy;bNational Institute of Nuclear Physics, INFN, Section of Pavia, Italy;cDepartment of Chemistry ‘UgoSchi’ & CSGI, University of Florence, Florence, Italy;dDISCAFF, University of Eastern Piedmont, Novara, Italy;eDipartimento di Scienze Clinico-Chirurgiche, Diagnostiche e Pediatriche, Universit degli Studidi Pavia, Italy |
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| Abstract: | AimBoron Neutron Capture Therapy (BNCT) is a binary hadrontherapy which exploits the neutron capture reaction in boron, together with a selective uptake of boronated substances by the neoplastic tissue. There is increasing evidence that future improvements in clinical BNCT will be triggered by the discovery of new boronated compounds, with higher selectivity for the tumor with respect to clinically used sodium borocaptate (BSH) and boronophenylalanine (BPA).BackgroundTherefore, a 10B quantification technique for biological samples is needed in order to evaluate the performance of new boronated formulations.Materials and methodsThis article describes an improved neutron autoradiography set-up employing radiation sensitive films where the latent tracks are made visible by proper etching conditions.ResultsCalibration curves for both liquid and tissue samples were obtained.ConclusionsThe obtained calibration curves were adopted to set-up a mechanism to point out boron concentration in the whole sample. |
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| Keywords: | Boron Neutron Capture Therapy Boron concentration Neutron autoradiography CR-39 |
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