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Sorting nexin 27 interacts with Fzd7 and mediates Wnt signalling
Authors:Lixiang Sun  Xiuyong Hu  Wanming Chen  Wei He  Zhiming Zhang  Tuanlao Wang
Affiliation:*School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Xiamen University, Xiamen 361102, Fujian, China;The First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian, China
Abstract:SNX27 is the only sorting nexin (SNX) that contains a PDZ domain, which interacts with PDZ-binding motif of target proteins to regulate the trafficking of these proteins. We here showed that SNX27 interacts with Frizzled (Fzd) receptors via PDZ domain interaction. Immunofluorescence microscopy revealed that Fzd7 can be internalized and associate with SNX27-containing endosomal membrane. In addition, SNX27 enhances the endocytosis of Fzd7 and promotes the degradation of Fzd7. Further examination demonstrated that SNX27 inhibits the Wnt regulated transcription activity of TCF/LEF. Our results suggested that SNX27 interacts with Frizzled receptors to regulate the endocytosis and stability of Fzds, and consequently mediates canonical Wnt signalling.
Keywords:Fzd7   PDZ domain   SNX27   Wnt signalling
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