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Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML
Institution:1. Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan;2. Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;3. Center for Information Biology, National Institute of Genetics, Shizuoka, Japan;4. Department of Leukemia, Section of Molecular Hematology and Therapy, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 448, Houston, TX 77030, United States;5. Preventive Medicine and Diagnosis Innovation Program, RIKEN Center for Life Science Technologies, Kanagawa, Japan;6. Department of Hematology, Juntendo University Graduate School of Medicine, Tokyo, Japan;7. Laboratory of Molecular Targeted Therapeutics, School of Pharmacy, Nihon University, Chiba, Japan;8. Division of Chemotherapy, Faculty of Pharmacy, Keio University, Tokyo, Japan;9. Department of Medicine, Indiana University School of Medicine, Marion, IN, United States;10. Department of Leukemia, Section of Leukemia Biology Research, The University of Texas MD Anderson Cancer Center, Houston, TX, United States;11. Kabushiki Kaisya Dnaform, Yokohama, Japan;12. Department of Next Generation Hematology Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
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