Synthesis and antibacterial activity of N-[2-(5-bromothiophen-2-yl)-2-oxoethyl] and N-[(2-5-bromothiophen-2-yl)-2-oximinoethyl] derivatives of piperazinyl quinolones |
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Authors: | Foroumadi Alireza Emami Saeed Mehni Massood Moshafi Mohammad Hassan Shafiee Abbas |
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Institution: | Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran. |
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Abstract: | A series of N-2-(5-bromothiophen-2-yl)-2-oxoethyl] and N-2-(5-bromothiophen-2-yl)-2-oximinoethyl]derivatives of piperazinyl quinolones were synthesized and evaluated for antimicrobial activity against Gram-positive and Gram-negative microorganisms. Some of these derivatives exhibit comparable or better activity against Gram-positive bacteria, Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis, than ciprofloxacin, norfloxacin and enoxacine as reference drugs. |
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