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| 倍他洛尔立体拆分菌株的筛选与鉴定 | |
| 引用本文： | 李永红,黄利华,刘宏民,黄科学.倍他洛尔立体拆分菌株的筛选与鉴定[J].工业微生物,2009,39(3):17-20. |
| 作者姓名： | 李永红 黄利华 刘宏民 黄科学 |
| 作者单位： | 1. 郑州大学新药研究开发中心,河南郑州,450052;郑州大学化学系,河南郑州,450052 2. 郑州大学新药研究开发中心,河南郑州,450052;郑州大学药学院,河南郑州,450001 3. 湖南师范大学生命科学学院,湖南长沙,410081;Company of Microbial,ID,USA |
| 摘 要： | 从土壤中分离到的52株微生物中，经筛选得到一个能立体选择性水解倍他洛尔中间体的菌株。根据个体形态特征和茵落形态特征初步确定其为红酵母，根据16SDNA序列最后确定其为胶红酵母（Rhodotorula mucilaginosa）DQ832198。该菌株可用于化学酶法制备左旋倍他洛尔的研究。 |
| 关 键 词： | 菌株筛选 鉴定 倍他洛尔 立体选择性水解 |
Screening and identification of microorganism for enantioselective hydrolysis of betaxolol intermediate |
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| LI Yong-hong,HUANG Li-hua,LIU Hong-min,HUANG Ke-xue.Screening and identification of microorganism for enantioselective hydrolysis of betaxolol intermediate[J].Industrial Microbiology,2009,39(3):17-20. | |
| Authors: | LI Yong-hong HUANG Li-hua LIU Hong-min HUANG Ke-xue |
| Institution: | LI Yong-hong, HUANG Li-hua, LIU Hong-min, HUANG Ke-xue (1. New Drug Research＆Development Center, Zhengzhou University, Zhengzhou450052,henan, China; 2.Chemistry Deparmaent, Zhengzhou University, Zhengzhou450052,henan, CAnna; 3. School of pharmaceutical Sciences, Zhengzhou University, Zhengzhou450052,henan; 4. College of Life Science, Hunan Normal University, Changsha,410081,hunan; 5. Cxrmpany of Microbial ID, USA) |
| Abstract: | 52 strains were isolated from soil samples and a microzyme with high preference for enantioselective hydrolysis of betaxolol intermediate was obtained. The strain was identified as RhodotoruAz firstly byits charcateristics of individual form and colony form, and finally identified as Rhodotorula mucilaginosa DQ832198 by its 16S DNA sequence. It could be used for the preparation of S-betaxolol by chemo-enzymatic method. |
| Keywords: | screening identification betaxolol enantioselective hydrolysis |
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