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A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges |
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| Authors: | Han Quan-Bin Yang Ling Wang Yu-Lin Qiao Chun-Feng Song Jing-Zheng Sun Han-Dong Xu Hong-Xi |
| Institution: | Laboratory of Chinese Medicine, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, PR China. |
| Abstract: | Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin-resistant K562/R cell lines (Table 2). |
| Keywords: | Garcinia hanburyi Xanthors polyprenylated Gambogic acid 30‐hydroxy‐Epigambogic acid 30‐hydroxy‐Cytotoxic activity Doxorubicin |
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