Antileishmanial physalins from Physalis minima |
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| Authors: | Choudhary M Iqbal Yousaf Sammer Ahmed Shakil;Samreen Yasmeen Kauser;Atta-ur-Rahman |
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| Institution: | H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. |
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| Abstract: | Three new physalins (1-3) and a new withanolide 7 have been isolated from the whole plant of Physalis minima, along with three known physalins: physalin H (4), isophysalin B (5), and 5beta,6beta-epoxyphysalin B (6). Their structures were deduced on the basis of in-depth spectroscopic analyses. Compounds 1-6 showed significant in vitro leishmanicidal activities (0.92-19.4 microg/ml) against promastigotes of Leishmania major. |
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