Intracerebroventricular somatostatin attenuates electroconvulsive shock-induced amnesia in rats |
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Authors: | László Vécsei Ibolya Bollók Gyula Telegdy |
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Institution: | Department of Pathophysiology, University Medical School, Szeged P.O.B. 531, H-6701, Hungary |
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Abstract: | In the present study the effect of intracerebroventricularly (ICV) administered somatostatin on electroconvulsive shock- (ECS) induced retrograde amnesia was investigated in rats. The ECS significantly decreased foot shock-induced avoidance latency. Somatostatin in a dose of (ICV) had no action on the ECS-induced retrograde amnesia, while in a dose of it significantly increased the avoidance latency if the treatment was performed immediately, 4 hr, 20 hr or 23 hr after the ECS. The results suggest that ICV administered somatostatin has an antiamnesic effect. |
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Keywords: | Somatostatin Electroconvulsive shock Amnesia Passive avoidance Rats |
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