Alterations in central neurotransmitter receptor binding sites following estradiol implantation in female rats |
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Authors: | C Goetz S Bourgoin F Cesselin A Brandi D Bression M Martinet F Peillon M Hamon |
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Institution: | 7. INSERM U 114, Collège de France, 11, Place M. Berthelot, 75231 Paris Cedex 05, France;2. INSERM U 223, CHU Pitié-Salpêtrière, 105, Bld de l''Hôpital, 75634 Paris Cedex 13, France;3. Sandoz Ltd., 14, Bld Richelieu, 92500 Rueil-Malmaison, France |
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Abstract: | The subcutaneous implantation of an estradiol pellet (10 mg) into female rats induced a hypophyseal hyperplasia with hyperprolactinaemia. Examination of neurotransmitter receptors in the hippocampus, striatum and cerebral cortex one month after the implantation revealed that estrogenization was associated with: an increased density of 3H-domperidone binding sites (D2 receptors) in the striatum and reduced numbers of 3H-serotonin high affinity sites (5-HT1 receptors) in the hippocampus and of 3H-muscimol binding sites (GABA receptors) in the hippocampus, striatum and cerebral cortex. In contrast, the characteristics of 3H-spiperone binding to 5-HT2 receptors (in the cerebral cortex) and those of 3H-flunitrazepam binding to benzodiazepine sites (in the three brain regions examined) were not significantly different in estrogenized and in control female rats. However, the enhancing effect of GABA on 3H-flunitrazepam binding was markedly reduced in brain membranes from estrogenized animals. The respective roles of estradiol and prolactin in mediating these changes in neurotransmitter receptors are discussed notably with regard to the regional heterogeneity of estradiol binding capacity in the rat brain. |
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Keywords: | To whom correspondence should be addressed |
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